We study the molecular pharmacology of G-Protein Coupled Receptors (GPCRs; focusing mainly on the Proteinase Activated Receptor family) and Transient Receptor Potential (TRP) ion channels. We use various techniques to understand cell-signaling responses to GPCRs and TRP channel activation at the molecular level and in vivo. These studies have relevance to various human diseases including cancer, cardiovascular diseases and inflammatory diseases such as colitis and asthma. |