GPCR mediated EGFR transactivation regulates TRPV4 action in the vasculature.
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Neutrophil elastase and proteinase-3 trigger G protein-biased signaling through proteinase-activated receptor-1 (PAR1).
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TRPM8 activation attenuates inflammatory responses in mouse models of colitis.
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Neutrophil elastase acts as a biased agonist for proteinase-activated receptor-2 (PAR2).
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Proteinases, their extracellular targets, and inflammatory signalling.
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Targeting proteinase-activated receptors: therapeutic potential and challenges
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Structure, function and pathophysiology of proteinase activated receptors.
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