We study the molecular pharmacology of G Protein-Coupled Receptors (GPCRs), focusing mainly on the Proteinase Activated Receptors (PARs) and Adhesion Family GPCRs (aGPCRs). We are also interested in Transient Receptor Potential (TRP) ion channels and crosstalk with GPCRs. We use various techniques to understand cell-signaling responses to GPCRs and TRP channel activation at the molecular level and in vivo. These studies have relevance to various human diseases including cancer, cardiovascular diseases and inflammatory diseases.