​Transient receptor potential vanilloid 4 regulates extracellular matrix composition and mediates load-induced intervertebral disc degeneration in a mouse model

Min Kyu Mark Kim, Matthew Lawrence, Diana Quinonez, Courtney Brooks, Rithwik Ramachandran, Cheryle A Séguin
​S. aureus drives itch and scratch-induced skin damage through a V8 protease-PAR1 axis

Liwen Deng, Flavia Costa, Kimbria J Blake, Samantha Choi, Arundhasa Chandrabalan, Muhammad Saad Yousuf , Stephanie Shiers, Daniel Dubreuil, Daniela Vega-Mendoza, Corinne Rolland, Celine Deraison, Tiphaine Voisin, Michelle D Bagood, Lucia Wesemann, Abigail M Frey, Joseph S Palumbo, Brian J Wainger, Richard L Gallo, Juan-Manuel Leyva-Castillo, Nathalie Vergnolle, Theodore J Price, Rithwik Ramachandran, Alexander R Horswill, Isaac M Chiu
​Autocrine proteinase-activated receptor signaling in PC3 prostate cancer cells

Arundhasa Chandrabalan and Rithwik Ramachandran
​Human osteoarthritis knee joint synovial fluids cleave and activate Proteinase-Activated Receptor (PAR) mediated signaling

Arundhasa Chandrabalan, Andrew Firth, Robert B Litchfield, C Thomas Appleton, Alan Getgood, Rithwik Ramachandran
​Protease-Activated Receptor 4 inhibition reduces coronary artery atherosclerosis and myocardial fibrosis in scavenger receptor class B type 1/low density lipoprotein receptor double knockout mice.

Samuel K. Lee, Rida Malik, Ji Zhou, Wei Wang, Peter Gross, Jeffrey Weitz, Rithwik Ramachandran and Bernardo Triggati.
​Molecular basis for activation and biased signalling at the thrombin-activated GPCR Proteinase Activated Receptor-4 (PAR4)

Pierre E Thibeault, Jordan C LeSarge, D'Arcy Arends, Michaela Fernandes, Peter Chidiac, Peter B Stathopulos, Leonard G Luyt, Rithwik Ramachandran.

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Targeting a PAR4 carboxyl terminal motif to regulate platelet function.
GPCR mediated EGFR transactivation regulates TRPV4 action in the vasculature. 
Neutrophil elastase and proteinase-3 trigger G protein-biased signaling through proteinase-activated receptor-1 (PAR1).
TRPM8 activation attenuates inflammatory responses in mouse models of colitis.
Neutrophil elastase acts as a biased agonist for proteinase-activated receptor-2 (PAR2).

Reviews
Proteinases, their extracellular targets, and inflammatory signalling. 
Targeting proteinase-activated receptors: therapeutic potential and challenges
Structure, function and pathophysiology of proteinase activated receptors.